Production of ADHD Drug Vyvanse Set to Go Up in Light of Shortages

As the shortage of medications to treat attention deficit hyperactivity disorder (ADHD) drags on, some relief may be on the way: The U.S. Drug Enforcement Administration (DEA) has approved a production increase for branded and generic versions of Vyvanse (lisdexamfetamine).

Total output of branded and generic versions of Vyvanse can climb by about 24 percent this year, a move requested by the U.S. Food and Drug Administration (FDA) to ease ADHD medication shortages.

“I was surprised to see the news, and I feel that every little bit will help,” says Jennifer McWilliams, MD, the division chief of pediatric psychiatry at Children’s Nebraska hospital and medical center in Omaha. “With that said, the shortages are so widespread that I don’t anticipate it will have a huge impact.”

“As people were forced to switch from Adderall to different medications, there (was) a domino effect of shortages,” Dr. McWilliams says. “That will take a while to undo.”

ADHD Drugs Are Considered Controlled Substances

Adderall, Vyvanse, and other stimulants for ADHD are considered controlled substances because they have a high potential for addiction and overdose. The DEA restricts prescription refills and sets manufacturing quotas for these medicines to limit the potential for misuse. But the FDA and DEA said that drugmakers shipped even fewer doses than permitted under the quotas in 2022, contributing to shortages that have yet to completely ease up.

And manufacturing quotas and production shortfalls are only part of the problem, says Lauren Hoffman, PharmD, a pharmacy clinical specialist in psychiatry at University Hospitals Cleveland Medical Center and Case Western Reserve University in Ohio.